Sommario
A cosa servono Avodart?
Avodart viene impiegato per trattare i soggetti di sesso maschile con prostata ingrossata (iperplasia prostatica benigna) – un aumento di tipo non maligno del volume della prostata, dovuto ad una produzione eccessiva di un ormone chiamato diidrotestosterone. Il principio attivo è la dutasteride.
Come agisce il dutasteride?
La dutasteride riduce i livelli sierici di diidrotestosterone (DHT) inibendo l’enzima 5-alfa-reduttasi, sia l’isoforma di tipo 1 sia di tipo 2, responsabile della trasformazione del testosterone in DHT. L’effetto del farmaco si manifesta entro 1-2 settimane con una riduzione di diidrotestosterone intorno al 90%.
Are there any clinical trials conducted with Duodart?
There have been no clinical trials conducted with Duodart; however, coadministration information for years 1 and 2 is available from the CombAT (Combination of Avodart and Tamsulosin) study, a comparison of dutasteride 500 microgram and tamsulosin 400 microgram once daily for four years as co-administration or as monotherapy.
What is Avodart (dutasteride)?
Avodart 1 Avodart (dutasteride) prevents the conversion of testosterone to… 2 Important information. Avodart should never be taken by a woman or a child. 3 Before taking this medicine. Using Avodart may increase your risk of developing prostate cancer. 4 Take Avodart exactly as prescribed by your doctor.
What are the side effects of Avodart?
Avodart side effects. Get emergency medical help if you have any of these signs of an allergic reaction to Avodart: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Less serious side effects may include: decreased libido (sex drive); decreased amount of semen released during sex;
What is Duodart made of?
The tamsulosin HCl component of Duodart consists of a multiunit pelletised preparation which has modified release properties. The individual pellets consist of a drug core and an outer coating layer which reduces the rate of dissolution of the drug. The single dose bioequivalence study was performed in both the fasted and fed states.